Equipoise abandoned? Randomization and clinical trials

Equipoise abandoned? Randomization and clinical trials.

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Equipoise in Clinical Trials

“Do you have equipoise?” The question was simple, yet loaded with challenges. We were being invited to participate in a prospective randomized controlled phase 3 trial testing whether acute endovascular stroke therapy can be beneficial for patients presenting beyond 6 hours from symptom onset (≤6 hours is the currently accepted therapeutic time window for mechanical thrombectomy) when using per...

Devices and clinical trials: overview and equipoise.

n an ideal world, our decision to enroll patients in clinical trials would be based on thoughtful, rational, informed, and balanced considerations of available and relevant scientific and clinical data. In reality, our decision making is based more often on our recent clinical experience and the opinions of those clinicians we value. To increase the appropriate and thoughtful enrollment of pati...

Clinical trials, devices, unproven treatments, and clinical equipoise.

Equipoise and the ethics of randomization.

It is widely accepted that randomized controlled clinical trials yield the most reliable evidence about the effects of clinical carel. In this article we discuss the ethical importance of 'equipoise'-the condition which applies when there is no preference between the treatment options to be compared. We ask whether equipoise is an essential prerequisite for an ethical trial: are trials ethical ...